With the release of macOS version 10.15 (Catalina), Apple is ending support for 32-bit applications.

Wolfram products based on Wolfram Language 12.0 or later are fully 64 bit on macOS, and are therefore compatible with macOS 10.15, as well as earlier versions.

Products based on earlier versions of the Wolfram Language contain 32-bit front ends on macOS, and work with macOS up to 10.14.6, but are not compatible with macOS 10.15 or later.
When starting a Wolfram product with a 32-bit front end on macOS 10.13.4 to 10.14.6, the OS may warn that the product “is not optimized for your Mac,” but it is fully functional on these macOS versions.

Mathematica is extremely useful for mathematicians, scientists, and engineers of all sorts. It has a learning curve, for sure, but once you learn it, there is an incredibly amount of power to harness. I use Mathematica 10 on MacBook Pro with macOS high Sierra 10.13.4 and when opening M10 got a message (see the screenshot) that M 10 is not optimised for Mac which means M10 is not running as 64 bit but as 32 bit app. M10 should be 64 bit app. Mathematica supports an X Window System front end, and uses the Qt application framework for its user interface—the same used by the major Linux desktop environment KDE. Regular tests are run on both enterprise and popular open-source Linux distributions.

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